abstract：:The reduction in the effectiveness of the blood-brain and blood-spinal cord barriers, previously seen in rats at the height of the acute episode of experimental allergic encephalomyelitis, has now been measured at various stages in the development of the disease up to 60 days after inoculation with guinea pig spinal c...

journal_title：Journal of the neurological sciences

authors： Daniel PM,Lam DK,Pratt OE

更新日期：1983-08-01 00:00:00

abstract：:In 13 patients with familial dysautonomia sleep recordings were obtained to investigate the possibility that autonomic nervous system dysfunction plays a role in disordered breathing during sleep. Sleep structure in some of our patients was abnormal, showing decreased amount of REM sleep and increased REM latencies. A...

journal_title：Journal of the neurological sciences

authors： Gadoth N,Sokol J,Lavie P

更新日期：1983-07-01 00:00:00

abstract：:A family with adult spinal and bulbar muscular atrophy with X-linked recessive inheritance (Kennedy's disease) is described. Affected members presented at age 20 with muscle cramps followed insidiously by gynaecomastia, partial loss of secondary sexual traits, loss of libido and inability to maintain an erection. Thre...

journal_title：Journal of the neurological sciences

authors： Arbizu T,Santamaría J,Gomez JM,Quílez A,Serra JP

更新日期：1983-06-01 00:00:00

abstract：:The scalp distribution of the response to stimulation of the tibial nerve at the medial malleolus was systematically analysed. The somatosensory evoked potential (SEP) was recorded with electrodes placed in a transversal line over the ipsilateral and contralateral postcentral gyri and in a sagittal line over the longi...

journal_title：Journal of the neurological sciences

authors： Berić A,Prevec TS

更新日期：1983-05-01 00:00:00

abstract：:Peripheral blood lymphocytes from patients with multiple sclerosis (MS), other neurological diseases and healthy controls were investigated for the presence of cell-mediated hypersensitivity to brain gangliosides and myelin basic protein using an active E-rosette assay. Sensitivity to myelin basic protein and ganglios...

journal_title：Journal of the neurological sciences

authors： Ilyas AA,Davison AN

更新日期：1983-04-01 00:00:00

abstract：:The stereotyped, episodic abnormal behaviour manifested by a child and her mother on exposure to a particular sort of sunlight is described in detail. The child is the first fully documented patient with this so-called "self-induced" form of photosensitive epilepsy in whom for several years no electroencephalographic ...

journal_title：Journal of the neurological sciences

authors： Ames FR,Saffer D

更新日期：1983-04-01 00:00:00

abstract：:The clinical features, results of nerve conduction studies and sural nerve biopsy findings have been compared in 5 patients with chronic relapsing polyneuropathy in whom plasma exchange was used in treatment. In 2 patients who consistently responded to plasma exchange, the dominant pathological findings was segmental ...

journal_title：Journal of the neurological sciences

authors： Pollard JD,McLeod JG,Gatenby P,Kronenberg H

更新日期：1983-02-01 00:00:00

abstract：:Muscle pain is the presenting symptom in patients with a wide variety of conditions. Such patients often pose problems in diagnosis and management and a rational scheme for their investigation is needed. The results of muscle biopsy, electromyography, exercise and strength testing and blood measurements in 109 consecu...

journal_title：Journal of the neurological sciences

authors： Mills KR,Edwards RH

更新日期：1983-01-01 00:00:00

abstract：:We cloned a previously characterized glioblastoma-derived parent cell line (12-18) in order to obtain a relatively homogenous population of human neural cells of neoplastic origin. These cells reach high densities in culture (over 100,000 cells/cm2) and have a high mean DNA content per cell of 18.1 +/- 0.9 pg. A histo...

journal_title：Journal of the neurological sciences

authors： Liepkalns VA,Icard-Liepkalns C,Sommer AM,Quigley JP

更新日期：1982-12-01 00:00:00

abstract：:The enzyme-linked immunosorbent assay (ELISA) was used to determine levels of specific IgG antibodies against measles, rubella, vaccinia, corona (OC43) and mumps viruses in cerebrospinal fluid (CSF) and serum of 18 patients with clinically definite multiple sclerosis (MS), 8 patients with optic neuritis (ON), 27 patie...

journal_title：Journal of the neurological sciences

authors： Leinikki P,Shekarchi I,Iivanainen M,Taskinen E,Holmes KV,Madden D,Sever JL

更新日期：1982-12-01 00:00:00

abstract：:A multidimensional quantitative EMG analysis method with averaged motor unit potentials (MUPs) was applied to a study of different stages of polymyositis. The duration parameters had a general tendency to increase in polymyositis. The only exception was the total MUP duration, which decreased in the onset stage of acu...

journal_title：Journal of the neurological sciences

authors： Partanen J,Lang H

更新日期：1982-12-01 00:00:00

abstract：:We evaluated 14 previously healthy dogs with acute progressive flaccid quadriparesis and hyporeflexia. Electrophysiological and pathological features indicated varying degrees of motor-sensory polyneuropathy with some demyelination. Perivenular cellular infiltrations were present in roots of one autopsied case. Recove...

journal_title：Journal of the neurological sciences

authors： Northington JW,Brown MJ

更新日期：1982-11-01 00:00:00

abstract：:In 1977 and 1978 Cook and his associates demonstrated a positive association between ownership of small dogs and both familial and sporadic cases of multiple sclerosis in New Jersey. Because of the far reaching implications of this work, a similar study was carried out and 72 patients with clinically definite multiple...

journal_title：Journal of the neurological sciences

authors： Read D,Nassim D,Smith P,Patterson C,Warlow C

更新日期：1982-09-01 00:00:00

abstract：:Recordings have been made from afferent fibres shown to traverse a focal demyelinating lesion induced in the dorsal columns of the cat by the direct micro-injection of lysophosphatidyl choline. Many fibres were spontaneously active, discharging with steady frequencies between 15 and 45 impulses per second or dischargi...

journal_title：Journal of the neurological sciences

authors： Smith KJ,McDonald WI

更新日期：1982-07-01 00:00:00

abstract：:Isometric contractions of single motor units in the first dorsal interosseous muscle were recorded with an intramuscular microstimulation technique in patients with short- or long-term hemiplegia and compared with controls. In the hemiplegic patients motor units could be classified as in controls, utilizing twitch con...

journal_title：Journal of the neurological sciences

authors： Young JL,Mayer RF

更新日期：1982-06-01 00:00:00

abstract：:The product of the permeability x vascular surface rate area (PA) of the blood-brain barrier to [14C]sucrose has been measured in rats raised on synthetic diets in which the saturated/unsaturated fat constitution was controlled at high or low levels. Gas-liquid chromatography demonstrated marked differences in brain f...

journal_title：Journal of the neurological sciences

authors： Phillips SC,Cragg BG,Sinclair AJ

更新日期：1982-05-01 00:00:00

abstract：:Editing of the video image in computerized image analysis is readily accomplished with the appropriate apparatus, but slows the assay very significantly. In dealing with the cerebral cortex, however video editing is of considerable importance in that cells are very often contiguous to one another or are partially supe...

journal_title：Journal of the neurological sciences

authors： Terry RD,Deteresa R

更新日期：1982-03-01 00:00:00

abstract：:This paper describes 2 brothers with increasingly severe exercise-induced muscle pain and stiffness, beginning in adolescence. Histochemical studies showed that myoadenylate deaminase activity was absent in the propositus, but present in his younger brother. Biochemical examination of muscle homogenates confirmed thes...

journal_title：Journal of the neurological sciences

authors： Hayes DJ,Summers BA,Morgan-Hughes JA

更新日期：1982-01-01 00:00:00

abstract：:Recently described techniques for separating myosin isoenzymes have been adapted for analysis of myosins from diseased and developing human skeletal muscle. The method is highly suitable for analysis of human myosins because only 2 - 3 mg of muscle are required for routine analyses. Human embryonic/foetal myosins are ...

journal_title：Journal of the neurological sciences

authors： Fitzsimons RB,Hoh JF

更新日期：1981-11-01 00:00:00

abstract：:Multiple sclerosis patients, control patients with other neurological diseases, and normal volunteers were assayed in a short-term 51chromium release assay for cell-mediated cytotoxicity against lymphocyte targets coated with myelin basic protein. Multiple sclerosis patients, compared to the other two groups, were hyp...

journal_title：Journal of the neurological sciences

authors： Eggers AE,Tarmin L,Plank CR,Gamboa ET

更新日期：1981-11-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) have been measured, by radioimmunoassay, in cerebral cortex obtained at autopsy from patients without neurological or psychiatric disease and from patients with Alzheimer's disease, depression and schizophrenia. Sephadex gel filtration indicated that over 9...

journal_title：Journal of the neurological sciences

authors： Perry RH,Dockray GJ,Dimaline R,Perry EK,Blessed G,Tomlinson BE

更新日期：1981-09-01 00:00:00

abstract：:HLA-A, B, and C antigens were determined in 52 patients with idiopathic Parkinson's disease and HLA-D antigens in 29 patients. In comparison with a representative sample of the Finnish general population, no significant deviations in HLA types of patients with Parkinson's disease were found. The patients with a slowly...

journal_title：Journal of the neurological sciences

authors： Marttila RJ,Rinne UK,Tiilikainen A

更新日期：1981-08-01 00:00:00

abstract：:A 70-year-old woman had complex behavioural changes of sudden onset. The symptoms consisted of indifference, docility and inappropriate urination, but predominantly in a lack of attention. She was unable to maintain the attention necessary to perform a goal-directed activity and she was distracted by any stimulus, suc...

journal_title：Journal of the neurological sciences

authors： Laplane D,Degos JD,Baulac M,Gray F

更新日期：1981-08-01 00:00:00

abstract：:Increased activity of the MM isoenzyme of creatine kinase (CK) was found in plasma from Bar Harbor dystrophic mice of the 129/ReJ dy/dy strain when compared to the findings in non-dystrophic controls. Total plasma CK activity was only slightly increased in dystrophic animals but plasma from both normal and dystrophic ...

journal_title：Journal of the neurological sciences

authors： Nicholson GA,Matheson E

更新日期：1981-07-01 00:00:00

abstract：:The intracellular content of the nervous system specific protein S-100 began to increase with 4 days latency following the morphological differentiation of cultured rat glioma cells (C-6) with 1 mM dibutyryl cyclic AMP (dbcAMP), rising to approximately 10-fold over the control level at 15 days after the treatment. The...

journal_title：Journal of the neurological sciences

authors： Tabuchi K,Furuta T,Norikane H,Tsuboi M,Moriya Y,Nishimoto A

更新日期：1981-07-01 00:00:00

abstract：:An unusual fatal congenital myopathy in a Chinese female infant is described. Muscle biopsy showed type I fibre smallness with central nuclei and focal decrease in oxidative enzyme activities affecting mainly larger type II fibres. Longitudinal sections from glutaldehyde-fixed araldite-embedded material stained with t...

journal_title：Journal of the neurological sciences

authors： Lee YS,Yip WC

更新日期：1981-05-01 00:00:00

abstract：:We have studied the regional distribution of glycoasparagine storage material in the brain in aspartylglycosaminuria, a condition characterized by inherited deficiency of lysosomal N-aspartyl-beta-N-acetylglucosamine amidohydrolase. Gaschromatographic measurements of the main accumulating glycoprotein-derived metaboli...

journal_title：Journal of the neurological sciences

authors： Maury CP,Haltia M,Palo J

更新日期：1981-05-01 00:00:00

abstract：:The permeability of the blood--brain barrier has been measured using a technique which is independent of blood flow and is sufficiently accurate to monitor the penetration of weakly permeant substances. The permeability of the blood--brain barrier to [14C]sucrose has been measured in rats anaesthetised with either ure...

journal_title：Journal of the neurological sciences

authors： Phillips SC

更新日期：1981-04-01 00:00:00

abstract：:Prefrontal corticofugal systems, as studied with anterograde HRP histochemistry, revealed projections to preoculomotor and oculomotor centers in the diencephalon and brainstem which may underlie direct cortical influence on eye movement. Because of the location of these preoculomotor trajectories, stimulation and lesi...

journal_title：Journal of the neurological sciences

authors： Leichnetz GR

更新日期：1981-03-01 00:00:00

abstract：:The internodal length of remyelinated internodes was examined by observations on teased CNS nerve fibres following primary demyelination induced by intraspinal injections of lysolecithin into the white matter of cats. A remyelinated internode was identified as a thinly-myelinated internode, where a node of Ranvier was...

journal_title：Journal of the neurological sciences

authors： Blakemore WF,Murray JA

更新日期：1981-02-01 00:00:00

abstract：:Muscle biopsies were obtained from the vastus lateralis of 14 male subjects: 3 long distance runners, 2 world class power lifters and 9 active, although not highly trained, individuals used as controls. The fibers were investigated by electron microscopy and the mitochondrial volume percent, lipid volume percent and Z...

journal_title：Journal of the neurological sciences

authors： Prince FP,Hikida RS,Hagerman FC,Staron RS,Allen WH

更新日期：1981-02-01 00:00:00

abstract：:The process of vascularisation was studied in transplanted astrocytomas in BD-IX rats. The development of blood vessels was followed from the earliest signs of angiogenesis throughout tumour growth. On the basis of tumour vasculature, 3 consecutive stages of tumour growth could be distinguished; avascular, early vascu...

journal_title：Journal of the neurological sciences

authors： Deane BR,Lantos PL

更新日期：1981-01-01 00:00:00

abstract：:The clinical value and practical application of the lumbosacral evoked electrospinogram (Espg) and somatosensory cerebral evoked potentials (SEP) were investigated in 52 patients with conus medullaris or cauda equina lesions. It was shown that the destruction or compression of the conus/cauda equina region by traumati...

journal_title：Journal of the neurological sciences

authors： Ertekin C,Mutlu R,Sarica Y,Uçkardeşler L

更新日期：1980-12-01 00:00:00

abstract：:Under electrophysiological control, a focal demyelinating lesion can be produced in the corpus callosum of the rabbit by slow pressure injection of a 1% solution of lysophosphatidyl choline (LPC). Light- and electron-microscopic examination of the LPC demyelinated corpus callosum indicates that many axons remain struc...

journal_title：Journal of the neurological sciences

authors： Foster RE,Kocsis JD,Malenka RC,Waxman SG

更新日期：1980-11-01 00:00:00

abstract：:A method is described which characterises the conduction deficit of a nerve in terms of the distribution of the refractory periods of transmission (RPTs) of its constituent fibres. The RPT is a particularly sensitive index of conduction deficit and measures the ability of a nerve fibre to conduct pairs of closely spac...

journal_title：Journal of the neurological sciences

authors： Smith KJ

更新日期：1980-11-01 00:00:00

abstract：:Fast and slow components of anterograde axoplasmic transport have been studied in the sensory fibres of the vagus nerve of alloxan-diabetic rabbits and age-matched controls by incorporation of tritiated leucine into nodose ganglion cells. The diabetic rabbits were maintained for 2 months with blood glucose levels in t...

journal_title：Journal of the neurological sciences

authors： Bajada S,Sharma AK,Thomas PK

更新日期：1980-09-01 00:00:00

abstract：:(1) Micro-electrode recordings of multi-unit sympathetic activity were attempted in skin or muscle branches of the peroneal nerve at the fibular head and the median nerve at the elbow in 41 patients with polyneuropathy of different causes. An indirect measure of sympathetic conduction velocity was obtained by determin...

journal_title：Journal of the neurological sciences

authors： Fagius J,Wallin BG

更新日期：1980-09-01 00:00:00

abstract：:Primary cultures prepared from human muscle biopsies were examined for the presence and distribution of acetylcholine receptors, as measured by the binding of 125iodine-labelled alpha-bungarotoxin. The toxin bound to the human muscle cultures with a similar time dependence and specificity as found in muscle cultures f...

journal_title：Journal of the neurological sciences

authors： Franklin GI,Yasin R,Hughes BP,Thompson EJ

更新日期：1980-09-01 00:00:00

abstract：:A broad spectrum of immunologic parameters was investigated in 13 cases of myotonic muscular dystrophy (MyD), including those for cellular immunity which has attracted little attention in the past. One was a 46-year-old woman having both MyD and a thymoma. This association between MyD and thymoma is probably coinciden...

journal_title：Journal of the neurological sciences

authors： Kuroiwa Y,Sugita H,Toyokura Y,Mizoguchi M,Matsuo H,Nonaka Y

更新日期：1980-08-01 00:00:00

abstract：:We show here that the major glycolipid in myelin, galactocerebroside, is not only a useful marker for isolated bovine oligodendrocytes but that its quantitation can serve as a probe for cell differentiation. We have produced in the rabbit antisera to bovine oligodendroglia, bovine myelin and galactocerebroside. The bi...

journal_title：Journal of the neurological sciences

authors： Steck AJ,Perruisseau G

更新日期：1980-07-01 00:00:00